BMP-12/GDF-7, human recombinant

Product name : BMP-12/GDF-7, human recombinant

Catalog number : 4572-100

Supplier : Biovision

Price : 588 EUR

Size : 100 μg

More about:

Classification : Small nuclear RNAs

Concept : Scope note: The initial culturing of cells derived directly from fresh TISSUES.

Discovery year : 1999-04-23

Entrez Gene : growth differentiation factor 11  (GDF11)

Entrez gene record : 151449

GenBank acession : AF522369

Gene : GDF7

Gene ontology - Biological process : regulation of apoptotic process negative regulation of cell proliferation palate development positive regulation of pathway-restricted SMAD protein phosphorylation regulation of MAPK cascade cell development SMAD protein signal transduction cell maturation negative regulation of cell differentiation spinal cord anterior/posterior patterning

Gene ontology - Cellular component : extracellular space nucleoplasm protein complex cellular_component intracellular membrane-bounded organelle

Gene ontology - Molecular function : protein binding growth factor activity cytokine activity transforming growth factor beta receptor binding

Havana BLAST/BLAT : OTTHUMG00000090781

Identity : 4222

InterPro : Transforming growth factor-beta, C-terminal Cystine-knot cytokine Transforming growth factor-beta-related Transforming growth factor beta, conserved site Transforming growth factor-beta, N-terminal

Locus : 2p24.1

Long gene name : growth differentiation factor 7

Name : Primary Cell Culture

PubMed : Myostatin or 20 ng/mL BMP-11 maintain the colony and cellular morphology of undifferentiated hESC, maintain POU5f1, NANOG, TRA-1-60, and SSEA4 expression, and display increased SMAD2/3 phosphorylation GDF11 inhibits the activity of the peroxisome proliferator-activated receptor gamma by promoting its SUMOylation. Members of the transforming growth factor beta (TGFbeta) superfamily, bone morphogenetic protein 2 (BMP2), and growth and differentiation factor 11 (GDF11), can signal cultured RGCs to form dendrites. We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development. These data demonstrate GDF11 to be a master regulator of neural stem cell transcription that can suppress cell proliferation and migration by regulating the expression of numerous genes involved in both these processes Suggest GDF11 functions as encephalic regionalizing factor in neural differentiated mouse embryonic stem cells. GDF11 inhibits rather than helps muscle regeneration. The crystal structure of GDF11 was determined to a resolution of 1.50 A. GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues. It functions in the heart, skeletal muscle, and brain. Review. MSTN, but not GDF11, declines in healthy men throughout aging.

Pubmed identfication : 10022976 9808626

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_182828

Synonyms : BMP12

Tree numbers : E01.370.225.500.223.500 E05.200.500.265.500 E05.242.223.500 E05.481.500.249.500