BMP-13, human recombinant

Product name : BMP-13, human recombinant

Catalog number : 4639-1000

Supplier : Biovision

Price : 1627 EUR

Size : 1 mg

More about:

Classification : Small nucleolar RNAs, C/D box

Concept : Scope note: The initial culturing of cells derived directly from fresh TISSUES.

Discovery year : 1999-04-23

Entrez Gene : BMP binding endothelial regulator  (BMPER)  (GDF11)

Entrez gene record : 392255

GenBank acession : AF250841

Gene : GDF6

Gene ontology - Biological process : ureteric bud development blood vessel endothelial cell proliferation involved in sprouting angiogenesis regulation of endothelial cell migration negative regulation of BMP signaling pathway endothelial cell activation endothelial cell differentiation inner ear development regulation of pathway-restricted SMAD protein phosphorylation positive regulation of ERK1 and ERK2 cascade

Gene ontology - Cellular component : extracellular space

Havana BLAST/BLAT : OTTHUMG00000164710

Identity : 4221

InterPro : VWFC domain BMP-binding endothelial regulator protein  (GDF11) von Willebrand factor, type D domain Uncharacterised domain, cysteine-rich Trypsin Inhibitor-like, cysteine rich domain

Locus : 8q22.1

Long gene name : growth differentiation factor 6

Name : Primary Cell Culture

PubMed : BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity Crossveinless-2 is an inhibitor of BMP function BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. BMPER-mediated signaling plays an essential role in vertebral segmentation early in human development, while defects in BMPER produce Diaphanospondylodysostosis. Diaphonospondylodysostosis is caused by loss of BMPER function. Mutual regulation by BMP-9 and CV2 is essential in regulating the development of the vascular endothelium. BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis. that BMPER-modulated BMP pathway activity regulates VE-cadherin expression and vascular barrier function

Pubmed identfication : 10022976 18425797

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_001001557

Synonyms : BMP13 KFS KFS1

Synonyms gene : SGM1

Synonyms gene name : segmentation syndrome 1

Tree numbers : E01.370.225.500.223.500 E05.200.500.265.500 E05.242.223.500 E05.481.500.249.500