BMP-15 Antibody

Product name : BMP-15 Antibody

Catalog number : E-AB-33727-20

Supplier : Elabscience

Price : 107.96 EUR

Size : 0.02 ml

More about:

Classification : Bone morphogenetic proteins

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1999-01-29

Entrez Gene : BMP binding endothelial regulator  (BMPER)  (GDF11)

Entrez gene record : 9210

GenBank acession : AF082349

Gene : BMP15

Gene ontology - Biological process : ureteric bud development blood vessel endothelial cell proliferation involved in sprouting angiogenesis regulation of endothelial cell migration negative regulation of BMP signaling pathway endothelial cell activation endothelial cell differentiation inner ear development regulation of pathway-restricted SMAD protein phosphorylation positive regulation of ERK1 and ERK2 cascade

Gene ontology - Cellular component : extracellular space

Havana BLAST/BLAT : OTTHUMG00000021525

Identity : 1068

InterPro : VWFC domain BMP-binding endothelial regulator protein  (GDF11) von Willebrand factor, type D domain Uncharacterised domain, cysteine-rich Trypsin Inhibitor-like, cysteine rich domain

Locus : Xp11.22

Locus Specific Databases : Mental Retardation database

Long gene name : bone morphogenetic protein 15

Name : Blotting, Western

PubMed : Crossveinless-2 is an inhibitor of BMP function BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. BMPER-mediated signaling plays an essential role in vertebral segmentation early in human development, while defects in BMPER produce Diaphanospondylodysostosis. Diaphonospondylodysostosis is caused by loss of BMPER function. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis. BMPER-dependent pathway involved in high glucose induced alkaline phosphatase expression in vascular smooth muscle cells. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis. that BMPER-modulated BMP pathway activity regulates VE-cadherin expression and vascular barrier function

Pubmed identfication : 9849956

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_005448

Synonyms : GDF9B

Synonyms gene name : collagen, type I, alpha, receptor

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200