BMP-2

Product name : BMP-2

Catalog number : GWB-CC86ED

Supplier : genways

Price : 614 EUR

Size : 1 vial

More about:

Classification : Bone morphogenetic proteins Endogenous ligands

Discovery year : 2005-07-25

Entrez Gene : BMP binding endothelial regulator  (BMPER)  (GDF11)

Entrez gene record : 168667

GenBank acession : L42113

Gene : BMPER

Gene ontology - Biological process : ureteric bud development blood vessel endothelial cell proliferation involved in sprouting angiogenesis regulation of endothelial cell migration negative regulation of BMP signaling pathway endothelial cell activation endothelial cell differentiation inner ear development regulation of pathway-restricted SMAD protein phosphorylation positive regulation of ERK1 and ERK2 cascade

Gene ontology - Cellular component : extracellular space

Havana BLAST/BLAT : OTTHUMG00000128675

Identity : 24154

InterPro : VWFC domain BMP-binding endothelial regulator protein  (GDF11) von Willebrand factor, type D domain Uncharacterised domain, cysteine-rich Trypsin Inhibitor-like, cysteine rich domain

Locus : 7p14.3

Long gene name : BMP binding endothelial regulator

PubMed : BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity Crossveinless-2 is an inhibitor of BMP function BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. BMPER-mediated signaling plays an essential role in vertebral segmentation early in human development, while defects in BMPER produce Diaphanospondylodysostosis. Diaphonospondylodysostosis is caused by loss of BMPER function. Mutual regulation by BMP-9 and CV2 is essential in regulating the development of the vascular endothelium. BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. BMPER-dependent pathway involved in high glucose induced alkaline phosphatase expression in vascular smooth muscle cells. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis.

Pubmed identfication : 12897139 14766204

RefSeq identity : NM_133468

Synonyms : Cv2 CRIM3

Synonyms gene : BMP2A

Synonyms name : crossveinless-2