BMP-2 Polyclonal Antibody

Product name : BMP-2 Polyclonal Antibody

Catalog number : CAA47407

Supplier : Biomatik

Price : Place ask EUR

Size : 50ug

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Classification : Endogenous ligands

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1997-09-12

Entrez Gene : BMP binding endothelial regulator  (BMPER)  (GDF11)

Entrez gene record : 2658

GenBank acession : AF156891

Gene : GDF2

Gene ontology - Biological process : ureteric bud development blood vessel endothelial cell proliferation involved in sprouting angiogenesis regulation of endothelial cell migration negative regulation of BMP signaling pathway endothelial cell activation endothelial cell differentiation inner ear development regulation of pathway-restricted SMAD protein phosphorylation positive regulation of ERK1 and ERK2 cascade

Gene ontology - Cellular component : extracellular space

Havana BLAST/BLAT : OTTHUMG00000188320

Identity : 4217

InterPro : VWFC domain BMP-binding endothelial regulator protein  (GDF11) von Willebrand factor, type D domain Uncharacterised domain, cysteine-rich Trypsin Inhibitor-like, cysteine rich domain

Locus : 10q11.22

Long gene name : growth differentiation factor 2

Name : Blotting, Western

PubMed : BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity Crossveinless-2 is an inhibitor of BMP function BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Diaphonospondylodysostosis is caused by loss of BMPER function. Mutual regulation by BMP-9 and CV2 is essential in regulating the development of the vascular endothelium. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis. that BMPER-modulated BMP pathway activity regulates VE-cadherin expression and vascular barrier function

Pubmed identfication : 10849432

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_016204

Synonyms : BMP-9 BMP9

Synonyms gene : BMP2A

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200