BMP 4 Blocking Peptide

Product name : BMP 4 Blocking Peptide

Catalog number : 33R-10583

Supplier : fitzgerald

Price : 414 EUR

Size : 50 µg

More about:

Classification : Endogenous ligands

Discovery year : 1997-09-12

Entrez Gene : BMP binding endothelial regulator  (BMPER)  (GDF11)

Entrez gene record : 2662

GenBank acession : L42113

Gene : GDF10

Gene ontology - Biological process : ureteric bud development blood vessel endothelial cell proliferation involved in sprouting angiogenesis regulation of endothelial cell migration negative regulation of BMP signaling pathway endothelial cell activation endothelial cell differentiation inner ear development regulation of pathway-restricted SMAD protein phosphorylation positive regulation of ERK1 and ERK2 cascade

Gene ontology - Cellular component : extracellular space

Havana BLAST/BLAT : OTTHUMG00000188319

Identity : 4215

InterPro : VWFC domain BMP-binding endothelial regulator protein  (GDF11) von Willebrand factor, type D domain Uncharacterised domain, cysteine-rich Trypsin Inhibitor-like, cysteine rich domain

Locus : 10q11.22

Long gene name : growth differentiation factor 10

PubMed : BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity Crossveinless-2 is an inhibitor of BMP function BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. BMPER-mediated signaling plays an essential role in vertebral segmentation early in human development, while defects in BMPER produce Diaphanospondylodysostosis. Diaphonospondylodysostosis is caused by loss of BMPER function. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis. that BMPER-modulated BMP pathway activity regulates VE-cadherin expression and vascular barrier function

Pubmed identfication : 8679252

RefSeq identity : NM_004962

Synonyms : BMP-3b