BMP-4 Blocking Peptide

Product name : BMP-4 Blocking Peptide

Catalog number : 5674RBP-50

Supplier : Biovision

Price : 153 EUR

Size : 50 μg

More about:

Classification : Bone morphogenetic proteins Endogenous ligands

Discovery year : 1990-06-11

Entrez Gene : BMP binding endothelial regulator  (BMPER)  (GDF11)

Entrez gene record : 652

GenBank acession : AF035427

Gene : BMP4

Gene ontology - Biological process : ureteric bud development blood vessel endothelial cell proliferation involved in sprouting angiogenesis regulation of endothelial cell migration negative regulation of BMP signaling pathway endothelial cell activation endothelial cell differentiation inner ear development regulation of pathway-restricted SMAD protein phosphorylation positive regulation of ERK1 and ERK2 cascade

Gene ontology - Cellular component : extracellular space

Havana BLAST/BLAT : OTTHUMG00000140303

Identity : 1071

InterPro : VWFC domain BMP-binding endothelial regulator protein  (GDF11) von Willebrand factor, type D domain Uncharacterised domain, cysteine-rich Trypsin Inhibitor-like, cysteine rich domain

Locus : 14q22.2

Long gene name : bone morphogenetic protein 4

PubMed : BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity Crossveinless-2 is an inhibitor of BMP function BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Diaphonospondylodysostosis is caused by loss of BMPER function. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. BMPER-dependent pathway involved in high glucose induced alkaline phosphatase expression in vascular smooth muscle cells. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis. that BMPER-modulated BMP pathway activity regulates VE-cadherin expression and vascular barrier function

Pubmed identfication : 7558046 7579580

RefSeq identity : NM_001202

Synonyms : BMP-3b

Synonyms gene : BMP2B