BMP-4 (human) ELISA Kit (For Lysates)

Product name : BMP-4 (human) ELISA Kit (For Lysates)

Catalog number : K4746-100

Supplier : Biovision

Price : 809 EUR

Size : 100 assays

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Classification : Bone morphogenetic proteins Endogenous ligands

Concept : Scope note: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Discovery year : 1990-06-11

Entrez Gene : BMP and activin membrane bound inhibitor  (BAMBI)  (GDF11)

Entrez gene record : 652

GenBank acession : AF035427

Gene : BMP4

Gene ontology - Biological process : cell migration positive regulation of cell proliferation positive regulation of transcription, DNA-templated positive regulation of protein binding regulation of cell shape positive regulation of canonical Wnt signaling pathway transforming growth factor beta receptor signaling pathway positive regulation of epithelial to mesenchymal transition negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of catenin import into nucleus

Gene ontology - Cellular component : cytoplasm plasma membrane integral component of membrane

Gene ontology - Molecular function : frizzled binding type II transforming growth factor beta receptor binding

Havana BLAST/BLAT : OTTHUMG00000140303

Identity : 1071

InterPro : BMP and activin membrane-bound inhibitor  (BAMBI)  (GDF11)

Kegg : TGF-beta signaling pathway - Homo sapiens (human) Wnt signaling pathway - Homo sapiens (human)

Locus : 14q22.2

Long gene name : bone morphogenetic protein 4

Name : Enzyme-Linked Immunosorbent Assay

PubMed : Observational study of gene-disease association. (HuGE Navigator) study demonstrates that LPS- and TNF-alpha-induced NF-kappaBp50-HDAC1 interaction represses BAMBI transcriptional activity, which contributes to TLR4-mediated enhancement of TGF-beta signaling in hepatic stellate cells during liver fibrosis. Observational study of gene-disease association. (HuGE Navigator) BAMBI interacts with Wnt receptor Frizzled5, coreceptor LRP6, and Dishevelled2 and increases the interaction between Frizzled5 and Dishevelled2 BAMBI was linked to a potentially aggressive tumor phenotype and predicted tumor recurrence and cancer-related death in CRC. Authors demonstrate for the first time a nuclear co-translocation of BAMBI with Smad2/3 upon TGF-geta treatment. Moreover, overexpression of BAMBI in an in vitro model led to significantly increased proliferation. Expression of the TGF pseudoreceptor BAMBI in the human lung, which is upregulated in response to nontypeable Haemophilus influenzae infection in COPD lung tissue in vivo and in vitro. Data show that hepatoprotective effects of adiponectin include induction of BAMBI which is reduced in human fatty liver. Overexpression of BAMBI is associated with the growth and invasion of human osteosarcoma. betacatenin expression was downregulated as a result of knocking down of BAMBI, and TGF-beta was downregulated in a similar manner.

Pubmed identfication : 7558046 7579580

Qualifiers : adverse effects, classification, economics, history, instrumentation, methods, mortality, nursing, psychology, standards, trends, utilization, veterinary, statistics & numerical data, contraindications, ethics

RefSeq identity : NM_001202

Synonyms : BMP-3b

Synonyms gene : BMP2B

Tree numbers : E05.478.566.350.170 E05.478.566.380.360 E05.478.583.400.170 E05.601.470.350.170 E05.601.470.380.360

WikiPathWays : TGF-beta Receptor Signaling