BMP-7 Antibody

Product name : BMP-7 Antibody

Catalog number : E-AB-30658-20

Supplier : Elabscience

Price : 107.96 EUR

Size : 0.02 ml

More about:

Classification : Endogenous ligands

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2014-08-08

Entrez Gene : BMP binding endothelial regulator  (BMPER)  (GDF11)

Entrez gene record : 102723590

GenBank acession : L42113

Gene : BMP7-AS1

Gene ontology - Biological process : ureteric bud development blood vessel endothelial cell proliferation involved in sprouting angiogenesis regulation of endothelial cell migration negative regulation of BMP signaling pathway endothelial cell activation endothelial cell differentiation inner ear development regulation of pathway-restricted SMAD protein phosphorylation positive regulation of ERK1 and ERK2 cascade

Gene ontology - Cellular component : extracellular space

Havana BLAST/BLAT : OTTHUMG00000032810

Identity : 40096

InterPro : VWFC domain BMP-binding endothelial regulator protein  (GDF11) von Willebrand factor, type D domain Uncharacterised domain, cysteine-rich Trypsin Inhibitor-like, cysteine rich domain

Locus : 20q13.31

Long gene name : BMP7 antisense RNA 1

Name : Blotting, Western

PubMed : Crossveinless-2 is an inhibitor of BMP function BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. Mutual regulation by BMP-9 and CV2 is essential in regulating the development of the vascular endothelium. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs. these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. BMPER-dependent pathway involved in high glucose induced alkaline phosphatase expression in vascular smooth muscle cells. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis.

Pubmed identfication : 8679252

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NR_110631

Synonyms : BMP-3b

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200