BMP And Activin Membrane Bound Inhibitor Homolog (BAMBI) ELISA kit

Product name : BMP And Activin Membrane Bound Inhibitor Homolog (BAMBI) ELISA kit

Catalog number : SEJ566Hu

Supplier : cclone

Price : 812 EUR

Size : 1 kit/96-well plate

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Classification : Endogenous ligands

Concept : Scope note: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Discovery year : 1997-09-12

Entrez Gene : BMP and activin membrane-bound inhibitor  (BAMBI)  (GDF11)

Entrez gene record : 2662

GenBank acession : L42113

Gene : GDF10

Gene ontology - Biological process : cell migration positive regulation of cell proliferation positive regulation of transcription, DNA-templated positive regulation of protein binding regulation of cell shape positive regulation of canonical Wnt signaling pathway transforming growth factor beta receptor signaling pathway positive regulation of epithelial to mesenchymal transition negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of catenin import into nucleus

Gene ontology - Cellular component : cytoplasm plasma membrane membrane integral component of membrane

Gene ontology - Molecular function : frizzled binding

Havana BLAST/BLAT : OTTHUMG00000188319

Identity : 4215

InterPro : BMP and activin membrane-bound inhibitor  (BAMBI)  (GDF11)

Kegg : Wnt signaling pathway - Mus musculus (mouse) TGF-beta signaling pathway - Mus musculus (mouse)

Locus : 10q11.22

Long gene name : growth differentiation factor 10

Name : Enzyme-Linked Immunosorbent Assay

PubMed : BAMBI protein is expressed in endothelial cells and is regulated by autophagy and lysosomal degradation. and has implications in tumor progression. Genomic organization of the mouse Nma/BAMBI gene and confirmed the chromosomal mapping to human chromosome 10 and mouse chromosome 2. Transcript levels of TGF-betas and their intracellular effectors correlated directly with genes encoding opioid peptides, whereas BAMBI correlated inversely. Overexpression of Nma/BAMBI in mouse odontoblast-like cell line MD10-A2 down-regulated expression of DSPP by 66% and up-regulated expression of DMP1 four-fold. we provide in vitro and in vivo evidence that BAMBI contributes to endothelial and vascular homeostasis suggest that BAMBI is involved in negative feedback loops that restrain the TGF-beta remodeling signals to protect the pressure-overloaded myocardium from uncontrolled extracellular matrix deposition in humans and mice these results provide strong evidence for an important role of endothelium rather than platelet BAMBI as a positive regulator of both thrombus formation and stability. BAMBI modulates the effects of diabetes on glomerular permselectivity in association with altered ERK1/2 and Smad1/5 signaling. BAMBI is required for normal C2C12 differentiation, and that its role in myogenesis is mediated by the Wnt/beta-catenin pathway.

Pubmed identfication : 8679252

Qualifiers : adverse effects, classification, economics, history, instrumentation, methods, mortality, nursing, psychology, standards, trends, utilization, veterinary, statistics & numerical data, contraindications, ethics

RefSeq identity : NM_004962

Synonyms : BMP-3b

Synonyms gene name : BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)

Tree numbers : E05.478.566.350.170 E05.478.566.380.360 E05.478.583.400.170 E05.601.470.350.170 E05.601.470.380.360

WikiPathWays : TGF Beta Signaling Pathway