BMP Binding Endothelial Regulator (BMPER) ELISA kit

Product name : BMP Binding Endothelial Regulator (BMPER) ELISA kit

Catalog number : SEJ548Hu

Supplier : cclone

Price : 812 EUR

Size : 1 kit/96-well plate

More about:

Classification : Endogenous ligands

Concept : Scope note: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Discovery year : 1997-09-12

Entrez Gene : BMP-binding endothelial regulator  (BMPER)  (GDF11)

Entrez gene record : 2662

GenBank acession : L42113

Gene : GDF10

Gene ontology - Biological process : ureteric bud development blood vessel endothelial cell proliferation involved in sprouting angiogenesis regulation of endothelial cell migration negative regulation of BMP signaling pathway endothelial cell activation endothelial cell differentiation inner ear development regulation of pathway-restricted SMAD protein phosphorylation positive regulation of ERK1 and ERK2 cascade

Gene ontology - Cellular component : extracellular space extracellular region

Gene ontology - Molecular function : protein binding

Havana BLAST/BLAT : OTTHUMG00000188319

Identity : 4215

InterPro : VWFC domain BMP-binding endothelial regulator protein  (GDF11) von Willebrand factor, type D domain Uncharacterised domain, cysteine-rich Trypsin Inhibitor-like, cysteine rich domain

Locus : 10q11.22

Long gene name : growth differentiation factor 10

Name : Enzyme-Linked Immunosorbent Assay

PubMed : The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. The context-dependent functional relationship between Tsg and Cv2 during mouse development, is presented. Development of the vertebral morphogenetic field is reported in the interactions of CV-2 and Twg. The data indicate a role for CV2 and Chd in the establishment of the vertebral morphogenetic field through the long-range relocalization of Chd/BMP complexes. Inhibition of BMP activity protects epithelial barrier function in lung injury. Cv2 is a conserved, positive regulator of bone morphogenetic protein signaling. Its cysteine-rich domains acts as both positive and negative modulators of BMP signaling. crossveinless 2 has essential pro-Bmp functions for locally restricted signal enhancement in multiple aspects of mammalian organogenesis. Cv2 may specify cardiac mesodermal lineage through inhibition of BMP signaling at early stage of cardiogenesis. BMPER-induced BMP signaling promotes coronary artery remodeling.

Pubmed identfication : 8679252

Qualifiers : adverse effects, classification, economics, history, instrumentation, methods, mortality, nursing, psychology, standards, trends, utilization, veterinary, statistics & numerical data, contraindications, ethics

RefSeq identity : NM_004962

Synonyms : BMP-3b

Synonyms name : crossveinless-2

Tree numbers : E05.478.566.350.170 E05.478.566.380.360 E05.478.583.400.170 E05.601.470.350.170 E05.601.470.380.360