Burkholderia vietnamiensis ATP-dependent protease ATPase subunit HslU (hslU)

Product name : Burkholderia vietnamiensis ATP-dependent protease ATPase subunit HslU (hslU)

Catalog number : GEN1249777.Baculovirus

Supplier : MBS Recombinant

Price : 2249 EUR

Size : 100ug

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Alternative name : Burkholderia vietnamiensis adenosine triphosphate-dependent protease ATPase functionnal sequence HslU (hslU)

Alternative names : ATP-dependent protease ATP-binding subunit HslU; ATP-dependent protease ATPase subunit HslU; ATP-dependent protease ATP-binding subunit HslU; Unfoldase HslU

Classification : VPS9 domain containing

Concept : Scope note: An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies.

Discovery year : 2000-09-20

Entrez Gene : caseinolytic mitochondrial matrix peptidase proteolytic subunit  (CLPP)

Entrez gene record : 9605

Expression system : Baculovirus

GenBank acession : AB018551

Gene : VPS9D1

Gene name : hslU

Gene ontology - Biological process : protein homooligomerization proteolysis involved in cellular protein catabolic process

Gene ontology - Cellular component : mitochondrion mitochondrial matrix endopeptidase Clp complex

Gene ontology - Molecular function : serine-type endopeptidase activity protein binding identical protein binding peptidase activity

Gene target : Burkholderia   vietnamiensis   ATP-dependent   protease   ATPase   subunit   HslU   (hslU)  

General description : ATP-dependent protease ATPase subunit HslU(hslU) is a recombinant protein expressed in Baculovirus . The protein can be with or without a His-Tag or other tag in accordance to customer's request. All of our recombinant proteins are manufactured in strictly controlled facilities and by using a well established technology which guarantees full batch-to-bact consistency and experiment reproducibility.

Havana BLAST/BLAT : OTTHUMG00000173219

Identity : 13526

InterPro : ClpP/crotonase-like domain ATP-dependent Clp protease proteolytic subunit  (VPS9D1) ClpP, histidine active site ClpP, Ser active site Clp protease proteolytic subunit /Translocation-enhancing protein TepA

Locus : 16q24.3

Long gene name : VPS9 domain containing 1

Long name : Recombinant Burkholderia vietnamiensis ATP-dependent protease ATPase subunit HslU (hslU)

Name : Radioallergosorbent Test

Other gene names : hslU; hslU;

PubMed : the N-terminal peptide of ClpP is a structural component of the substrate translocation channel and may play an important functional role as well hClpX can regulate the appearance of hClpP peptidase activity in mitochondria and might affect the nature of the degradation products released during ATP-dependent proteolytic cycles We propose that decreased levels of mitochondrial proteases Lon and ClpP may allow heat shock protein 60 substrate proteins to go through more folding attempts Deletion of PaClpP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina and This phenotype can be reverted by expression of human ClpP. Perrault syndrome is caused by recessive mutations in CLPP. Optical trapping to assay single-molecule ClpXP unfolding and translocation of substrates consisting of domains with varying stabilities and sequences; find that ClpXP unfolds most domains by a single pathway, with kinetics that depend on the native fold and structural stability. ClpP proteases from E. coli, S. aureus, and human mitochondria exhibit preferences for certain amino acids in the P1, P2, and P3 positions . ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2, CLPP and C10orf2 Data indicate endopeptidase Clp (ClpP) mutation identified in two patients with Perrault syndrome type 3 in a Turkish family. Data suggest that tumors exploit ClpXP-directed proteostasis to maintain mitochondrial bioenergetics, buffer oxidative stress, and enable metastatic competence.

Pubmed identfication : 10231027

Qualifiers : adverse effects, classification, economics, history, instrumentation, methods, mortality, nursing, psychology, standards, trends, utilization, veterinary, statistics & numerical data, contraindications, ethics

RefSeq identity : NM_004913

Short name : Burkholderia vietnamiensis ATP-dependent protease ATPase subunit HslU (hslU)

Synonyms : ATP-BL

Synonyms gene : C16orf7

Synonyms gene name : chromosome 16 open reading frame 7

Tree numbers : E01.370.225.812.735.830 E05.200.812.735.830 E05.478.566.380.810 E05.478.566.639.810 E05.478.594.760.830 E05.601.470.380.810 E05.601.470.639.810