Burkholderia vietnamiensis Transcriptional repressor NrdR (nrdR)

Product name : Burkholderia vietnamiensis Transcriptional repressor NrdR (nrdR)

Catalog number : GEN1089270.Baculovirus

Supplier : MBS Recombinant

Price : 1520 EUR

Size : 100ug

More about:

Concept : Scope note: An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies.

Entrez Gene : dehydrogenase/reductase 4  (DHRS4L1)

Expression system : Baculovirus

Gene :

Gene ontology - Biological process : oxidation-reduction process alcohol metabolic process protein tetramerization steroid metabolic process retinol metabolic process cellular ketone metabolic process

Gene ontology - Cellular component : nucleus extracellular exosome endoplasmic reticulum membrane mitochondrion peroxisome peroxisomal membrane

Gene ontology - Molecular function : receptor binding oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NADP-retinol dehydrogenase activity carbonyl reductase (NADPH) activity 3-keto sterol reductase activity alcohol dehydrogenase [NAD(P) ] activity

General description : Transcriptional repressor NrdR (nrdR) is a recombinant protein expressed in Baculovirus . The protein can be with or without a His-Tag or other tag in accordance to customer's request. All of our recombinant proteins are manufactured in strictly controlled facilities and by using a well established technology which guarantees full batch-to-bact consistency and experiment reproducibility.

InterPro : Short-chain dehydrogenase/reductase, conserved site Short-chain dehydrogenase/reductase SDR  (DHRS7)  (SDR9C7) NAD(P)-binding domain  (HMGA1P8) Dehydrogenase/reductase SDR member 4-like  (DHRS4L1)  (SDR9C7)

Kegg : Peroxisome - Homo sapiens (human) Retinol metabolism - Homo sapiens (human)

Long gene name :

Name : Radioallergosorbent Test

PubMed : Observational study of gene-disease association. (HuGE Navigator) Alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 is associated with cervical squamous carcinoma Results suggest a novel mechanism of cold inactivation and role of the inducible human DHRS4 in 3beta-hydroxysteroid synthesis and xenobiotic carbonyl metabolism Novel alternative splicing variants, transcribed from an alternative transcrioption start sites within the DHRS4 gene cluster were identified in this study. Analysis of exon composition in the transcripts of DHRS4 gene cluster revealed that exon 1 was absent in all the transcripts initiated from exon a1 of DHRS4L2 and exon a2 of DHRS4L1. This study demonstrates that AS1DHRS4, as a long noncoding RNA, simultaneously controls the chromatin state of each gene within the DHRS4 gene cluster in a discriminative manner. A rapid evolution rate brought the human DHRS2 gene, duplicated form of the DHRS4 one, to code a SDR enzyme having subcellular localization, synthesis regulation and specialized cellular functions very different from those of the human DHRS4 enzyme. NRDRB1, an alternatively spliced isoform of NRDR in vivo functions better than NRDR as a dicarbonyl reductase for xenobiotics containing reactive carbonyls. AS1eRNA-driven DNA looping and activating histone modifications promote the expression of DHRS4-AS1 to economically control the DHRS4 gene cluster. An analysis of the relationship between the promoter characteristics and RNA expression of the DHRS4 gene cluster indicated that the development of CpG islands, in addition to the promoter sequence, during mammalian evolution could modulate the dose compensatory regulation of the copy number-varied DHRS4 gene cluster

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Tree numbers : E01.370.225.812.735.830 E05.200.812.735.830 E05.478.566.380.810 E05.478.566.639.810 E05.478.594.760.830 E05.601.470.380.810 E05.601.470.639.810