Burkholderia vietnamiensis UDP-N-acetylenolpyruvoylglucosamine reductase (murB)

Product name : Burkholderia vietnamiensis UDP-N-acetylenolpyruvoylglucosamine reductase (murB)

Catalog number : GEN1213382.Mammalian Cell

Supplier : MBS Recombinant

Price : 2509 EUR

Size : 100ug

More about:

Alternative name : Burkholderia vietnamiensis UDP-N-acetylenolpyruvoylglucosamine reductase (murB)

Alternative names : UDP-N-acetylenolpyruvoylglucosamine reductase; UDP-N-acetylenolpyruvoylglucosamine reductase; UDP-N-acetylenolpyruvoylglucosamine reductase; UDP-N-acetylmuramate dehydrogenase

Alternative technique : elisa

Classification : RAS type GTPase family

Concept : Scope note: Radioimmunoassay of proteins using antibody coupled to an immunosorbent.

Discovery year : 2001-06-22

Entrez Gene : UDP-galactose-4-epimerase  (GALE)  (GBGT1)  (JPD)

Entrez gene record : 4893

Expression system : Mammalian Cell

GenBank acession : BC005219

Gene : NRAS

Gene name : murB

Gene ontology - Biological process : galactose catabolic process

Gene ontology - Cellular component : cytosol extracellular exosome

Gene ontology - Molecular function : protein homodimerization activity identical protein binding UDP-N-acetylglucosamine 4-epimerase activity UDP-glucose 4-epimerase activity

Gene target : Burkholderia   vietnamiensis   UDP-N-acetylenolpyruvoylglucosamine   reductase   (murB)  

General description : UDP-N-acetylenolpyruvoylglucosamine reductase (murB) is a recombinant protein expressed in Mammalian Cell . The protein can be with or without a His-Tag or other tag in accordance to customer's request. All of our recombinant proteins are manufactured in strictly controlled facilities and by using a well established technology which guarantees full batch-to-bact consistency and experiment reproducibility.

Havana BLAST/BLAT : OTTHUMG00000012059

Identity : 7989

InterPro : NAD(P)-binding domain  (HMGA1P8) NAD-dependent epimerase/dehydratase Nucleotide sugar epimerase UDP-glucose 4-epimerase GalE  (GALE)  (GBGT1)

Kegg : Galactose metabolism - Homo sapiens (human) Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)

Locus : 1p13.2

Locus Specific Databases : NRASbase: Mutation registry for autoimmune lymphoproliferative syndrome type IV LRG_92

Long gene name : NRAS proto-oncogene, GTPase

Long name : Recombinant Burkholderia vietnamiensis UDP-N-acetylenolpyruvoylglucosamine reductase (murB)

Name : Radioimmunosorbent Test

Other gene names : murB; murB;

PubMed : study of hGALE crystal structure and demonstration that residue 307 acts as a gatekeeper mediating substrate access to the hGALE active site Resulst describe the relationship among UDP-galactose 4'-epimerase activity, substrate specificity, metabolic balance, and galactose sensitivity in mammalian cells. Data suggest that reduced catalytic efficiency and increased proteolytic susceptibility of UDP-galactose 4-epimerase are causative factors in type III galactosemia. Subtle biochemical and metabolic abnormalities detected in patients expressing these GALE alleles likely reflect, at least in part, the reduced enzymatic activity of the encoded GALE proteins. Our observations show that altered protein stability is due to misfolding and that loss or reduction of enzyme activity is responsible for the molecular defects underlying GALE-deficiency galactosemia. P.K161N-hGALE causes its effects by abolishing an important interaction between the protein and the cofactor. human UDP-galactose 4'-epimerase stability is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding These data indicated a critical role of GALE in maintaining cartilage homeostasis, and suggested that GALE inhibition might contribute to OA progress. Data show the protein structure of GALE and its substrate binding and specificity. It is mutated in type III galactosemia. [review] Mutation in UDP-galactose-4'-epimerase gene is associated with UDP-galactose-4'-epimerase deficiency.

Pubmed identfication : 6705568 11524732

Qualifiers : adverse effects, classification, economics, history, instrumentation, methods, mortality, nursing, psychology, standards, trends, utilization, veterinary, statistics & numerical data, contraindications, ethics

RefSeq identity : NM_002524

Short name : Burkholderia vietnamiensis UDP-N-acetylenolpyruvoylglucosamine reductase (murB)

Synonyms : N-ras

Synonyms gene name : neuroblastoma RAS viral (v-ras) oncogene homolog neuroblastoma RAS viral oncogene homolog

Tree numbers : E05.478.566.380.830 E05.478.566.639.830 E05.601.470.380.830 E05.601.470.639.830