Product name : Burkholderia vietnamiensis UDP-N-acetylmuramate--L-alanine ligase (murC)
Catalog number : GEN1024296.Mammalian Cell
Supplier : MBS Recombinant
Price : 2807 EUR
Size : 100ug
Alternative name : Burkholderia vietnamiensis UDP-N-acetylmuramate--L-alanine ligase (murC)
Alternative names : UDP-N-acetylmuramate--L-alanine ligase; UDP-N-acetylmuramate--L-alanine ligase; UDP-N-acetylmuramate--L-alanine ligase; UDP-N-acetylmuramoyl-L-alanine synthetase
Alternative technique : immunoglobulin-a
Classification : RAS type GTPase family
Concept : Scope note: A DNA amplification technique based upon the ligation of OLIGONUCLEOTIDE PROBES. The probes are designed to exactly match two adjacent sequences of a specific target DNA. The chain reaction is repeated in three steps in the presence of excess probe: (1) heat denaturation of double-stranded DNA, (2) annealing of probes to target DNA, and (3) joining of the probes by thermostable DNA ligase. After the reaction is repeated for 20-30 cycles the production of ligated probe is measured.
Discovery year : 2001-06-22
Entrez Gene : alanyl-tRNA synthetase 2, mitochondrial (AARS2)
Entrez gene record : 4893
Expression system : Mammalian Cell
GenBank acession : BC005219
Gene : NRAS
Gene name : murC
Gene ontology - Biological process : mitochondrial respiratory chain complex assembly tRNA modification mitochondrial alanyl-tRNA aminoacylation
Gene ontology - Cellular component : mitochondrion
Gene ontology - Molecular function : ATP binding metal ion binding tRNA binding amino acid binding alanine-tRNA ligase activity
Gene target : Burkholderia vietnamiensis UDP-N-acetylmuramate L-alanine ligase (murC)
General description : UDP-N-acetylmuramate--L-alanine ligase (murC) is a recombinant protein expressed in Mammalian Cell . The protein can be with or without a His-Tag or other tag in accordance to customer's request. All of our recombinant proteins are manufactured in strictly controlled facilities and by using a well established technology which guarantees full batch-to-bact consistency and experiment reproducibility.
Havana BLAST/BLAT : OTTHUMG00000012059
Identity : 7989
InterPro : Translation protein, beta-barrel domain Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain (IBSP) Alanyl-tRNA synthetase, class IIc, core domain Alanyl-tRNA synthetase, class IIc, N-terminal Threonyl/alanyl tRNA synthetase, SAD Alanine-tRNA ligase, class IIc Alanine-tRNA ligase, eukaryota/bacteria Alanine-tRNA ligase, class IIc, anti-codon-binding domain
Kegg : Aminoacyl-tRNA biosynthesis - Homo sapiens (human)
Locus : 1p13.2
Locus Specific Databases : NRASbase: Mutation registry for autoimmune lymphoproliferative syndrome type IV LRG_92
Long gene name : NRAS proto-oncogene, GTPase
Long name : Recombinant Burkholderia vietnamiensis UDP-N-acetylmuramate--L-alanine ligase (murC)
Name : Ligase Chain Reaction
Other gene names : murC; murC; Bcep1808_0536
PubMed : Observational study of gene-disease association. (HuGE Navigator) Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients A new phenotype caused by AARS2 mutations is characterized by leukoencephalopathy and ovarian failure in female patients, indicating that the phenotypic spectrum associated with AARS2 variants is much wider than previously reported. we describe a Japanese woman with novel compound heterozygous mutations in AARS2, the first report of leukodystrophy caused by AARS2 mutations in Asia. This paper documented a new, nonsense AARS2 gene mutation (c.578T>G, p.Leu193*) and a known missense mutation (c.595C>T, p.Arg199Cys) associated with leukoencephalopathy in a male patient. Mutations in AARS2 in a Series of CSF1R-Negative Patients With Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia.
Pubmed identfication : 6705568 11524732
Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
RefSeq identity : NM_002524
Short name : Burkholderia vietnamiensis UDP-N-acetylmuramate--L-alanine ligase (murC)
Synonyms : N-ras
Synonyms gene name : neuroblastoma RAS viral (v-ras) oncogene homolog neuroblastoma RAS viral oncogene homolog
Tree numbers : E05.393.620.311
