Product name : C2orf51 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)
Catalog number : LV093914
Supplier : ABM lentivectors
Price : 322.5 EUR
Size : 1.0 µg DNA
Classification : Phospholipases
Concept : Scope note: The in vitro fusion of GENES by RECOMBINANT DNA techniques to analyze protein behavior or GENE EXPRESSION REGULATION, or to merge protein functions for specific medical or industrial uses.
Discovery year : 2002-04-29
Entrez Gene : ubiquitin C (UBC)
Entrez gene record : 50487
GenBank acession : AF220490
Gene : PLA2G3
Gene ontology - Biological process : positive regulation of I-kappaB kinase/NF-kappaB signaling protein ubiquitination involved in ubiquitin-dependent protein catabolic process I-kappaB kinase/NF-kappaB signaling positive regulation of epidermal growth factor receptor signaling pathway stress-activated MAPK cascade stimulatory C-type lectin receptor signaling pathway negative regulation of type I interferon production virion assembly anaphase-promoting complex-dependent catabolic process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Gene ontology - Cellular component : nucleus cytosol plasma membrane extracellular exosome endoplasmic reticulum membrane endosome membrane vesicle endoplasmic reticulum quality control compartment endocytic vesicle membrane host cell
Gene ontology - Molecular function : protein binding RNA binding protease binding
Havana BLAST/BLAT : OTTHUMG00000151255
Identity : 17934
InterPro : Ubiquitin-related domain Ubiquitin domain (UBLCP1) Ubiquitin conserved site Ubiquitin (USP51)
Kegg : PPAR signaling pathway - Homo sapiens (human)
Locus : 22q12.2
Long gene name : phospholipase A2 group III
Name : Artificial Gene Fusion
PubMed : Data indicate that heat shock protein 90kDa (Hsp90) inhibition suppresses 26S proteasome remodeling, unanchored ubiquitin chain production, and aggresome clearance. The GP78 CUE domain functions to both facilitate substrate binding and enable switching between adjacent ubiquitin molecules of a growing chain to enable processivity in ubiquitination. The presence of ubiquitin mainly in the nuclei and in the cytoplasm of BPH and prostatic adenocarcinoma, respectively, may suggest a role of ubiquitin in the development of the above mentioned conditions The positive rates of ubiquitin and cul-1 were significantly higher in lung cancer than those in benign lesion tissues of the lung. provide insights into the pivotal role of Sp1/Sp3 binding to the intronic enhancer in the regulation of UbC transcription. Studies indicate that Ubiquitin- and SUMO-mediated modification pathways have emerged as key players in regulating damage-induced template switching. Data indicate that a single point deletion (DeltaE81) in RAP80 abrogates multivalent interactions with polyubiquitin. Our study predicted that UBC and RPA had potential as target genes for the diagnosis and treatment of osteosarcoma Upon stabilization of the protein's core, the long loop converges on the core in the final step of the folding process. Studies indicate complex ubiquitin architectures function as important signals including post-translational modification (PTM) of ubiquitin itself, such as acetylated ubiquitin and phospho-ubiquitin..
Pubmed identfication : 10713052
Qualifiers : drug effects, methods, radiation effects
RefSeq identity : NM_015715
Synonyms : GIII-SPLA2
Synonyms gene name : phospholipase A2, group III
Tree numbers : E05.393.220.250
WikiPathWays : Proteasome Degradation DNA Replication
