Product name : C2orf53 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)
Catalog number : LV093920
Supplier : ABM lentivectors
Price : 322.5 EUR
Size : 1.0 µg DNA
Classification : Phospholipases
Concept : Scope note: The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.
Discovery year : 2002-04-29
Entrez Gene : ubiquitin C (UBC)
Entrez gene record : 50487
GenBank acession : AF220490
Gene : PLA2G3
Gene ontology - Biological process : protein polyubiquitination MyD88-independent toll-like receptor signaling pathway I-kappaB kinase/NF-kappaB signaling TRIF-dependent toll-like receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process JNK cascade stimulatory C-type lectin receptor signaling pathway interstrand cross-link repair nucleotide-excision repair, DNA incision anaphase-promoting complex-dependent catabolic process
Gene ontology - Cellular component : extracellular space plasma membrane nucleoplasm extracellular exosome endoplasmic reticulum membrane endosome membrane myelin sheath vesicle endoplasmic reticulum quality control compartment host cell
Gene ontology - Molecular function : protein binding RNA binding protease binding
Havana BLAST/BLAT : OTTHUMG00000151255
Identity : 17934
InterPro : Ubiquitin-related domain Ubiquitin domain (UBLCP1) Ubiquitin conserved site Ubiquitin (USP51)
Kegg : PPAR signaling pathway - Homo sapiens (human)
Locus : 22q12.2
Long gene name : phospholipase A2 group III
Name : Transduction, Genetic
PubMed : Studies suggest that DNA damage-induced ubiquitination or sumoylation of PCNA prevents CRL4Cdt2-dependent degradation by inhibiting binding of Cdt1 to PCNA. Studies indicate that Non-proteolytic ubiquitylation of chromatin surrounding DSBs, mediated by the RNF8/RNF168 ubiquitin ligase cascade, has emerged as a key mechanism for restoration of genome integrity. Ubiquitin targeting of tau protein occurs at neurofibrillary tangles in the early and intermediate maturation stages. These results reveal an unanticipated mode of Ube2g2 self-association that allows Ube2g2 to effectively engage two ubiquitins to specifically synthesize Lys48-linked ubiquitin chains. Data indicate that a single point deletion (DeltaE81) in RAP80 abrogates multivalent interactions with polyubiquitin. Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2) and ring finger protein 4 (RNF4) together induce an active conformation of the ubiquitin-conjugating enzyme Ubc13-ubiquitin (Ubc13~Ub) thioester. noncovalent ubiquitin:ubiquitin interactions are nearly identical to those reported for Lys11-linked ubiquitin and seem to play a significant role in stabilizing the crystal structure without the isopeptide bond. Upon stabilization of the protein's core, the long loop converges on the core in the final step of the folding process. Studies indicate complex ubiquitin architectures function as important signals including post-translational modification (PTM) of ubiquitin itself, such as acetylated ubiquitin and phospho-ubiquitin.. Studies suggest that ubiquitin signals for the proteasome involved more that Lys48 (K48).
Pubmed identfication : 10713052
Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
RefSeq identity : NM_015715
Synonyms : GIII-SPLA2
Synonyms gene name : phospholipase A2, group III
Tree numbers : E05.393.350.800
WikiPathWays : Proteasome Degradation DNA Replication
