C2orf55 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

Product name : C2orf55 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

Catalog number : LV093968

Supplier : ABM lentivectors

Price : 1125 EUR

Size : 1.0 µg DNA

More about:

Classification : Phospholipases

Concept : Scope note: The in vitro fusion of GENES by RECOMBINANT DNA techniques to analyze protein behavior or GENE EXPRESSION REGULATION, or to merge protein functions for specific medical or industrial uses.

Discovery year : 2002-04-29

Entrez Gene : ubiquitin C  (UBC)

Entrez gene record : 50487

GenBank acession : AF220490

Gene : PLA2G3

Gene ontology - Biological process : negative regulation of transcription from RNA polymerase II promoter regulation of signal transduction by p53 class mediator positive regulation of canonical Wnt signaling pathway Fc-epsilon receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process cellular iron ion homeostasis nucleotide-binding oligomerization domain containing signaling pathway interstrand cross-link repair translesion synthesis

Gene ontology - Cellular component : nucleus cytosol plasma membrane nucleoplasm extracellular exosome endosome membrane myelin sheath endoplasmic reticulum quality control compartment mitochondrial outer membrane host cell

Gene ontology - Molecular function : protein binding RNA binding protease binding

Havana BLAST/BLAT : OTTHUMG00000151255

Identity : 17934

InterPro : Ubiquitin-related domain Ubiquitin domain  (UBLCP1) Ubiquitin conserved site Ubiquitin  (USP51)

Kegg : PPAR signaling pathway - Homo sapiens (human)

Locus : 22q12.2

Long gene name : phospholipase A2 group III

Name : Artificial Gene Fusion

PubMed : Studies suggest that DNA damage-induced ubiquitination or sumoylation of PCNA prevents CRL4Cdt2-dependent degradation by inhibiting binding of Cdt1 to PCNA. Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain provide insights into the pivotal role of Sp1/Sp3 binding to the intronic enhancer in the regulation of UbC transcription. The structure of UbcH8 does not undergo a significant conformational change upon forming a complex with ubiquitin. Studies indicate that the involvement of the degradation-linked K48-ubiquitin signal and the proteasome at the sites of DSBs. Studies indicate that Non-proteolytic ubiquitylation of chromatin surrounding DSBs, mediated by the RNF8/RNF168 ubiquitin ligase cascade, has emerged as a key mechanism for restoration of genome integrity. the ubiquitin independent degradation pathway utilized by a hepatitis B virus envelope protein limits antigen presentation The donor ubiquitin, transferred from the E2, is bound to the Nedd4 C lobe with its C-terminal tail locked in an extended conformation, primed for catalysis. Studies indicate a role for the ubiquitin-proteasome system (UPS) as a key regulator of ciliogenesis. Studies suggest that ubiquitin signals for the proteasome involved more that Lys48 (K48).

Pubmed identfication : 10713052

Qualifiers : drug effects, methods, radiation effects

RefSeq identity : NM_015715

Synonyms : GIII-SPLA2

Synonyms gene name : phospholipase A2, group III

Tree numbers : E05.393.220.250

WikiPathWays : Proteasome Degradation DNA Replication