C2orf68 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

Product name : C2orf68 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

Catalog number : LV094054

Supplier : ABM lentivectors

Price : 600 EUR

Size : 1.0 µg DNA

More about:

Classification : Phospholipases

Concept : Scope note: The in vitro fusion of GENES by RECOMBINANT DNA techniques to analyze protein behavior or GENE EXPRESSION REGULATION, or to merge protein functions for specific medical or industrial uses.

Discovery year : 2002-04-29

Entrez Gene : chromosome 2 open reading frame 68  (C2orf68)

Entrez gene record : 50487

GenBank acession : AF220490

Gene : PLA2G3

Havana BLAST/BLAT : OTTHUMG00000151255

Identity : 17934

InterPro : Uncharacterised protein family UPF0561

Locus : 22q12.2

Long gene name : phospholipase A2 group III

Name : Artificial Gene Fusion

PubMed : The mRNA levels of NM_001013649.3 are significantly down-regulated in colorectal adenocarcinoma tissue, and this down-regulation is most likely correlated with the differentiation status of the cancer. Observations of the current study indicate that hcrcn81 may play a role in tumorigenesis by regulating the mTOR signaling pathway. c2orf68 expression correlates with the pathogenesis of colorectal cancer through PI3K/Akt/mTOR pathway. hcrcn81 might promote carcinogenesis and progression through regulation of the Wnt/beta-catenin signaling pathway and plays an important role in the carcinogenesis of colorectal cancer.

Pubmed identfication : 10713052

Qualifiers : drug effects, methods, radiation effects

RefSeq identity : NM_015715

Synonyms : GIII-SPLA2

Synonyms gene name : phospholipase A2, group III

Tree numbers : E05.393.220.250