C2orf70 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

Product name : C2orf70 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

Catalog number : LV094070

Supplier : ABM lentivectors

Price : 600 EUR

Size : 1.0 µg DNA

More about:

Classification : Phospholipases

Concept : Scope note: The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.

Discovery year : 2002-04-29

Entrez Gene : ubiquitin C  (UBC)

Entrez gene record : 50487

GenBank acession : AF220490

Gene : PLA2G3

Gene ontology - Biological process : regulation of signal transduction by p53 class mediator positive regulation of NF-kappaB transcription factor activity regulation of necroptotic process positive regulation of apoptotic process macroautophagy positive regulation of epidermal growth factor receptor signaling pathway stimulatory C-type lectin receptor signaling pathway regulation of type I interferon production regulation of transcription from RNA polymerase II promoter in response to hypoxia viral life cycle

Gene ontology - Cellular component : extracellular space nucleus plasma membrane nucleoplasm extracellular exosome endosome membrane myelin sheath endoplasmic reticulum quality control compartment mitochondrial outer membrane host cell

Gene ontology - Molecular function : protein binding RNA binding protease binding

Havana BLAST/BLAT : OTTHUMG00000151255

Identity : 17934

InterPro : Ubiquitin-related domain Ubiquitin domain  (UBLCP1) Ubiquitin conserved site Ubiquitin  (USP51)

Kegg : PPAR signaling pathway - Homo sapiens (human)

Locus : 22q12.2

Long gene name : phospholipase A2 group III

Name : Transduction, Genetic

PubMed : Studies indicate that monoubiquitylation of PCNA allows mutagenic translesion synthesis by damage-tolerant DNA polymerases, polyubiquitylation is required mainly for an error-free pathway that likely involves template switching. Studies indicate that All the Y-family polymerases have ubiquitin binding domains that bind to mono-ubiquitinated PCNA to effect the switching from replicative to Y-family polymerase. The GP78 CUE domain functions to both facilitate substrate binding and enable switching between adjacent ubiquitin molecules of a growing chain to enable processivity in ubiquitination. The presence of ubiquitin mainly in the nuclei and in the cytoplasm of BPH and prostatic adenocarcinoma, respectively, may suggest a role of ubiquitin in the development of the above mentioned conditions Studies indicate that indicating that the inhibition of the ubiquitin-proteasome system could be used as a novel approach for cancer therapy. Studies indicate that Ubiquitin- and SUMO-mediated modification pathways have emerged as key players in regulating damage-induced template switching. Ubiquitin targeting of tau protein occurs at neurofibrillary tangles in the early and intermediate maturation stages. This article reviews the recent advances in proteomics of HMG20 and reveals novel networks and associations with human disease.[review] Studies indicate that ubiquitin proteasome system (UPS) controls all aspects of cholesterol metabolism including its synthesis, uptake, and efflux. noncovalent ubiquitin:ubiquitin interactions are nearly identical to those reported for Lys11-linked ubiquitin and seem to play a significant role in stabilizing the crystal structure without the isopeptide bond.

Pubmed identfication : 10713052

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_015715

Synonyms : GIII-SPLA2

Synonyms gene name : phospholipase A2, group III

Tree numbers : E05.393.350.800

WikiPathWays : Proteasome Degradation DNA Replication