Campylobacter curvus Serine hydroxymethyltransferase (glyA)

Product name : Campylobacter curvus Serine hydroxymethyltransferase (glyA)

Catalog number : GEN1198773.Mammalian Cell

Supplier : MBS Recombinant

Price : 2680 EUR

Size : 100ug

More about:

Concept : Scope note: A genus of bacteria found in the reproductive organs, intestinal tract, and oral cavity of animals and man. Some species are pathogenic.

Entrez Gene : serine hydroxymethyltransferase 2  (SHMT2)

Gene :

Gene ontology - Biological process : positive regulation of cell proliferation protein K63-linked deubiquitination protein homotetramerization protein tetramerization response to type I interferon tetrahydrofolate interconversion tetrahydrofolate metabolic process one-carbon metabolic process folic acid metabolic process L-serine biosynthetic process

Gene ontology - Cellular component : nucleus cytoplasm extracellular exosome mitochondrion mitochondrial matrix microtubule cytoskeleton mitochondrial intermembrane space mitochondrial inner membrane mitochondrial nucleoid BRISC complex

Gene ontology - Molecular function : protein binding chromatin binding identical protein binding pyridoxal phosphate binding amino acid binding glycine hydroxymethyltransferase activity L-allo-threonine aldolase activity

InterPro : Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase, major region, subdomain 2 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 Serine hydroxymethyltransferase, pyridoxal phosphate binding site Serine hydroxymethyltransferase  (SHMT1)

Kegg : Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) Glycine, serine and threonine metabolism - Homo sapiens (human) One carbon pool by folate - Homo sapiens (human)

Long gene name :

Name : Campylobacter

PubMed : Observational study of gene-disease association. (HuGE Navigator) The MECP-2 is the direct targets of miR-370 and miR-373, respectively, in human articular chondrocytes. Observational study of genetic testing. (HuGE Navigator) Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) AGL loss causes high SHMT2 expression and consequently increases glycine-dependent nucleotide synthesis leading to bladder cancer growth. SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis This paper compares the mitochondrial and cytoplasmic forms of this enzyme and suggests that the two genes are a result of a single gene duplication. Observational study of gene-disease association. (HuGE Navigator) The present study not only describes individual genetic variation that directly affects SHMT1 and SHMT2 activity, but provided insight into the overall regulation of the Folate and Methionine Cycles. our results for the first time showed that miR-615-5p prevents proliferation and migration through negatively regulating SHMT2 in HCC.

Qualifiers : classification, cytology, drug effects, enzymology, genetics, growth & development, immunology, isolation & purification, metabolism, pathogenicity, physiology, radiation effects, ultrastructure, chemistry, virology

Tree numbers : B03.440.180 B03.660.150.100

WikiPathWays : Vitamin B12 Metabolism Folate Metabolism One Carbon Metabolism Trans-sulfuration and one carbon metabolism One carbon metabolism and related pathways Glycine Metabolism