Campylobacter curvus Trigger factor (tig)

Product name : Campylobacter curvus Trigger factor (tig)

Catalog number : GEN1188718.Mammalian Cell

Supplier : MBS Recombinant

Price : 2746 EUR

Size : 100ug

More about:

Concept : Scope note: A genus of bacteria found in the reproductive organs, intestinal tract, and oral cavity of animals and man. Some species are pathogenic.

Entrez Gene : PKHD1, fibrocystin/polyductin  (PKHD1)

Gene :

Gene ontology - Biological process : single organismal cell-cell adhesion kidney development negative regulation of NF-kappaB transcription factor activity regulation of ERK1 and ERK2 cascade cellular calcium ion homeostasis cilium assembly regulation of TOR signaling homeostatic process regulation of centrosome duplication negative regulation of cellular component movement

Gene ontology - Cellular component : cytoplasm extracellular exosome integral component of membrane centrosome apical plasma membrane mitotic spindle ciliary basal body cilium chromosome, centromeric region anchored component of external side of plasma membrane

Gene ontology - Molecular function : protein binding receptor activity

InterPro : Immunoglobulin-like fold Immunoglobulin E-set IPT domain  (TRIT1) PA14 domain Parallel beta-helix repeat Pectin lyase fold Pectin lyase fold/virulence factor G8 domain Fibrocystin  (PKHD1)

Long gene name :

Name : Campylobacter

PubMed : Data suggest that the PI3K/Akt pathway is involved in apoptotic function in PKHD1-silenced cells, and PI3K/Akt inhibition correlates with upregulation of NF-kappaB activity. The intracellular C-terminus of fibrocystin interacts with CAML, a protein with an intracellular distribution that is similar to that of PKD2. polycystin-1, polycystin-2, and fibrocystin are shed in membrane particles in the urine, and these particles interact with primary cilia Both polycystins were detected on the spindle and mid-body of mitotic cells, while fibrocystin was on centrosome throughout cell cycle. PKHD1 gene product polyductin/fibrocystin undergoes a complicated pattern of Notch-like proteolytic processing and is shed from the cilia to the lumen. Mutations in this gene are not linked to renal-hepatic-pancreatic dysplasia in a case report. PKHD1 sequencing results on 78 ARPKD/CHF patients from 68 families, is reported. PKHD1 localizes to the mitotic spindle in patients with autosomal recessive polycystic kidney disease. PKHD1 mutations in a Chinese twin family with Caroli disease. Data show that the compound heterozygous mutations of c.11314C>T from mother and a missense c.889T>A from father of the polycystic kidney and hepatic disease 1 protein (PKHD1) gene were identified in the fetus.

Qualifiers : classification, cytology, drug effects, enzymology, genetics, growth & development, immunology, isolation & purification, metabolism, pathogenicity, physiology, radiation effects, ultrastructure, chemistry, virology

Tree numbers : B03.440.180 B03.660.150.100