Anti- GZMB Antibody

Product name : Anti- GZMB Antibody

Catalog number : GEN9126731

Supplier : MBS Polyclonals

Price : 558 EUR

Size : 0.2 mg

More about:

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1989-05-12

Entrez Gene : granzyme B

Entrez gene record : 3002

GenBank acession : BC030195

Gene : CSPB

Gene ontology - Biological process : proteolysis apoptotic process cytolysis granzyme-mediated apoptotic signaling pathway natural killer cell mediated cytotoxicity positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Gene ontology - Cellular component : nucleus cytosol membrane mitochondrion immunological synapse secretory granule

Gene ontology - Molecular function : serine-type endopeptidase activity protein binding serine-type peptidase activity

Havana BLAST/BLAT : OTTHUMG00000029369

Identity : 2462

InterPro : Peptidase S1, PA clan Serine proteases, trypsin family, serine active site Serine proteases, trypsin family, histidine active site Peptidase S1A, chymotrypsin family Serine proteases, trypsin domain

Kegg : Transcriptional misregulation in cancer - Homo sapiens (human) Natural killer cell mediated cytotoxicity - Homo sapiens (human) Apoptosis - Homo sapiens (human) Autoimmune thyroid disease - Homo sapiens (human) Allograft rejection - Homo sapiens (human) Type I diabetes mellitus - Homo sapiens (human) Graft-versus-host disease - Homo sapiens (human)

Locus : 14q12

Long gene name : granzyme B

Name : Blotting, Western

PubMed : expressed during acute cellular rejection episodes after kidney transplantation Mouse granzyme B is 30 times less cytotoxic than human granzyme B and does not require Bid for killing but regains cytotoxicity on engineering of its active site cleft. Mouse granzyme A is considerably more cytotoxic than human granzyme A. These data demonstrate that human and murine GzmB are distinct enzymes with different substrate preferences. Our observations also illustrate how subtle differences in enzyme structure can radically affect substrate selection. Granzyme B induces apoptosis of chondrocytes with natural killer cell-like cytotoxicity in rheumatoid arthritis 55 Q/Q genotype is associated with increased in vitro expression of granzyme B and is associated with allograft rejection in heart transplantation. cleavage of Notch1 by GrB resulted in a loss of transcriptional activity, independent of Notch1 activation. We conclude that GrB disables Notch1 function, probably resulting in anti-cellular proliferation and cell death signals. Common variable immunodeficiency patients with autoimmunity have elevated levels of activated T cells expressing granzyme B and HLA-DR. Our results reveal a dichotomy in human CL: CD8( ) granzyme B( )T cells mediate tissue injury, whereas CD4( )IFN-gamma( )T cells mediate leishmania parasite killing. results suggest a mechanism for how ATP increases TrkH activity by inducing conformational changes in TrkA these results suggest a perforin-independent, extracellular role for GzmB in the pathogenesis of cardiac fibrosis

Pubmed identfication : 2323780

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_004131


Synonyms gene : CTLA1

Synonyms gene name : granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Synonyms name : fragmentin 2 cytotoxic serine protease B cathepsin G-like 1 T-cell serine protease 1-3E granzyme 2 cytotoxic T-lymphocyte-associated serine esterase 1

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex Apoptosis Apoptotic Signaling Pathway Allograft Rejection Signaling by NOTCH2 Oxidative phosphorylation