Anti- GZMM Antibody

Product name : Anti- GZMM Antibody

Catalog number : GEN2517417

Supplier : MBS Polyclonals

Price : 348 EUR

Size : 0.12 ml

More about:

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1994-10-12

Entrez Gene : granzyme M  (GZMM)

Entrez gene record : 3004

Gene : GZMM

Gene ontology - Biological process : proteolysis apoptotic process innate immune response cytolysis cell death

Gene ontology - Cellular component : extracellular region membrane

Gene ontology - Molecular function : serine-type endopeptidase activity protein binding serine-type peptidase activity

Havana BLAST/BLAT : OTTHUMG00000180559

Identity : 4712

InterPro : Peptidase S1, PA clan Serine proteases, trypsin family, serine active site Serine proteases, trypsin family, histidine active site Peptidase S1A, chymotrypsin family Serine proteases, trypsin domain Granzyme M  (GZMM)

Locus : 19p13.3

Long gene name : granzyme M

Name : Blotting, Western

PubMed : FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. NPM is essential for cell viability, these data suggest that targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function. survivin cleavage by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells proteinase inhibitor 9 was effectively hydrolyzed and inactivated by human granzyme M, raising the possibility that this orphan granzyme bypasses proteinase inhibitor 9 inhibition of granzyme B GrM also exists extracellularly in plasma where it could play a physiological role in controlling blood coagulation by determining plasma FVIII levels via proteolytic processing of its carrier VWF. Structure-based mutagenesis reveals that the amino-terminus and catalytic triad of GzmM are most essential for proteolytic function. These findings support not only a role for GrM in the innate but also in the adaptive immune response. Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71. GrM is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K in the presence of RNA. We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain.

Pubmed identfication : 8119738

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_005317

Synonyms : MET1 LMET1

Synonyms gene name : granzyme M (lymphocyte met-ase 1)

Synonyms name : lymphocyte met-ase 1

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200