Anti- HLTF Antibody

Product name : Anti- HLTF Antibody

Catalog number : GEN2517407

Supplier : MBS Polyclonals

Price : 265 EUR

Size : 0.06 ml

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Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2011-07-28

Entrez Gene : helicase like transcription factor  (HLTF)

Gene : HLTF-AS1

Gene ontology - Biological process : regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter covalent chromatin modification protein ubiquitination protein polyubiquitination transcription from RNA polymerase II promoter postreplication repair

Gene ontology - Cellular component : nucleus cytoplasm nucleoplasm membrane nucleolus

Gene ontology - Molecular function : protein binding zinc ion binding ATP binding DNA binding RNA binding helicase activity ATPase activity ubiquitin protein ligase binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding

Havana BLAST/BLAT : OTTHUMG00000159531

Identity : 40554

InterPro : P-loop containing nucleoside triphosphate hydrolase Zinc finger, RING/FYVE/PHD-type  (MTMR3) Zinc finger, RING-type  (RNF113A) Zinc finger, RING-type, conserved site Helicase, C-terminal  (BRIP1) Helicase superfamily 1/2, ATP-binding domain  (VPS9D1) SNF2-related, N-terminal domain  (SMARCA4) Helicase-like transcription factor  (HLTF) HIRAN domain

Locus : 3q24

Long gene name : HLTF antisense RNA 1

Name : Blotting, Western

PubMed : HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue. Splice arrays and RT-PCR showed that although most splice variants in RUSH and ATP11B are conserved in human and rabbit, the RFBP isoform is specific to rabbit. There is an association between the presence of helicase-like transcription factor and neoplastic progression of hypopharyngeal and laryngeal squamous cell carcinomas. HLTF can promote error-free replication of damaged DNA and support a role for HLTF in preventing mutagenesis and carcinogenesis, providing thereby for its potential tumor suppressor role. results suggest that HLTF is involved in DNA repair and apoptosis in cancer cells, which might represent a target for gene therapies of human cancer HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV rays and methyl methanesulfonate. Results demonstrate that loss of HLTF function promotes the malignant transformation of intestinal or colonic adenomas to carcinomas by inducing genomic instability. HLTF promotes the filling-in of gaps left opposite damaged DNA during replication, and this postreplication repair function depends on its HIRAN domain. HLTF is degraded in lymphocytic cells and macrophages infected with Vpr-expressing HIV-1. Our results reveal a previously unidentified strategy for HIV-1 to antagonize DNA repair in host cells. Fasudil reduced LPS-mediated TF and PAI-1 expression and activity in PBMCs. These effects may partially be relevant to the clinical benefits of fasudil in the treatment of CAPD patients.

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

Synonyms gene name : HLTF antisense RNA 1 (non-protein coding)

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Retinoblastoma (RB) in Cancer