Product name : Bmp10 Antibody
Catalog number : abx029289
Supplier : abbex
Price : 406 EUR
Size : 400 μl
Classification : Bone morphogenetic proteins Endogenous ligands
Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Discovery year : 2003-04-16
Entrez Gene : bone morphogenetic protein 10 (BMP10)
Entrez gene record : 27302
GenBank acession : AF101441
Gene : BMP10
Gene ontology - Biological process : negative regulation of endothelial cell migration heart trabecula formation activin receptor signaling pathway negative regulation of cardiac muscle hypertrophy cardiac muscle cell proliferation pathway-restricted SMAD protein phosphorylation ventricular cardiac muscle cell development positive regulation of sarcomere organization regulation of cardiac muscle hypertrophy in response to stress positive regulation of cell proliferation involved in heart morphogenesis
Gene ontology - Cellular component : extracellular space cytoplasm extracellular region cell surface Z disc
Gene ontology - Molecular function : protein binding hormone activity growth factor activity cytokine activity receptor serine/threonine kinase binding transforming growth factor beta receptor binding telethonin binding
Havana BLAST/BLAT : OTTHUMG00000129573
Identity : 20869
InterPro : Transforming growth factor-beta, C-terminal Cystine-knot cytokine Transforming growth factor-beta-related Transforming growth factor beta, conserved site Transforming growth factor-beta, N-terminal Inhibin, alpha subunit (INHA)
Locus : 2p13.3
Locus Specific Databases : LRG_403
Long gene name : bone morphogenetic protein 10
Name : Blotting, Western
PubMed : Observational study of gene-disease association. (HuGE Navigator) Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) Observational study of gene-disease association. (HuGE Navigator) Observational study of gene-disease association. (HuGE Navigator) Bone morphogenetic protein (BMP)9 and BMP10 are high affinity ligands for activin receptor-like kinase 1 (ALK1). Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. Low expression of bone morphogenetic protein-10 is associated with urothelial cancer of the bladder. BMP10, is elevated in the stenotic colon segment of Hirschsprung disease patients, and BMP10 signaling may play a pivotal role in disease development. The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells.
Pubmed identfication : 10072785
Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
RefSeq identity : NM_014482
Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200
WikiPathWays : VEGFA-VEGFR2 Signaling Pathway Heart Development
